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Although non-steroidal anti-inflammatory drugs (NSAIDs) effectively relieve the pain and inflammation of osteoarthritis (OA), there remain suspicions that some, at least, may hinder the organised regrowth of cartilage.
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For example preparation of co-crystals of aceclofenac using chitosan, in which chitosan solution was prepared by soaking chitosan in glacial acetic acid.
However, the result of our study reflects practical clinical settings where patients have different kinds of comorbid conditions requiring different kinds of medications.
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Aceclofenac is the treatment of choice for patients and physicians in the management of inflammatory pain.
Compositions disclosed in the present invention, whether ready-to-use or requiring dilution prior to administration, can be prepared by inexpensive processes disclosed herein.
The results showed a marked increase in the rate of a second heart attack in people who were taking an anti-inflammatory compared to those who were not.
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The anti-inflammatory and analgesic efficacy of aceclofenac is similar to that of ketoprofen, indomethacin, tenoxicam and diclofenac in patients with rheumatoid arthritis.
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Conventional NSAIDs cause non-selective inhibition of cyclooxygenase, which leads to reduction in bicarbonate secretion and reduced mucous production (Raskin JB 1999).
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In this study content of diclofenac in three tablet formulation along with their respective marketed formulations were determined initially and after 6M accelerated stability study by using High performance liquid chromatography (HPLC).
Its effect on liver function relative to that of other NSAIDs remains to be determined.
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Aceclofenac (Biopharmaceutical classification Class II drug) is a novel non-steroidal anti-inflammatory drugs (NSAIDs) having anti-inflammatory and analgesic properties, and is widely used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
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The Aceclofenac formulation of any of Items 8 and 9, wherein concentration of said optional ethanol is within range from about 1% to about 30% by weight of said solvent liquid of claim 1, which is formed by mixture of said nonaqueous solubilizer component and said Aceclofenac salt stabilizer component.
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