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Thus, in men treated with castration, symptoms appear to be more severe and less prone to resolution than they are in postmenopausal women.

The clinical relevance of this has been shown in a recent Medical Research Council study in the United Kingdom involving 938 patients with locally advanced or asymptomatic metastatic prostate cancer.

Treatment of C4-2 cells with the MAP kinase inhibitor, UO126 in steroid depleted conditions, substantially decreases AR stability and protein expression, suggesting that enhanced autocrine growth factor signaling contributes to the maintenance of AR expression and facilitates AR activity in the absence of androgens.

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The influence of prior novel androgen receptor targeted therapy on the efficacy of cabazitaxel in men with metastatic castration-resistant prostate cancer.

First, there are very few trials investigating a direct comparison of two different treatment modalities (e.

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The test measures the levels of this genetic fragment and another genetic marker (PCA3) in urine which are detectable at high levels in men who have prostate cancer.

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Before going further, the urologist asked Larry if he had any questions.

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Nervous system side effects including dizziness, paresthesia, and insomnia have been reported.

Source: Journal of the American Medical Association, July 27, 2005.

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These axons come from the prostatic plexus, a collection of autonomic nerves and neurons that are trunks of the superior hypogastric plexus, a meshwork of nerves that lies anterior to the bifurcation of the aorta.

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However, another study found that low-dose bicalutamide administration resulted in testicular atrophy and reduced the count in the testes of male rats by almost 50%, though the rate of successful and pregnancy following was not assessed.

Stopping or slowing down the production of male hormones can slow down or stop the growth of prostate cancer cells, at least for a period of time that is not predictable at the present.

The historic investigations known as the Veterans Administration Cooperative Urological Research Group (VACURG) studies formed a basis for the treatment of prostate cancer with DES before the availability of LHRH analogues.

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The purpose of this visit is to discuss the role of radiation therapy in your treatment, to determine to be used, the treatment plan for your treatment, and to answer any questions you may have.

When Trial 24 data are combined with the data from the other two trials of the EPC programme, the overall EPC results demonstrate that, in patients with locally advanced prostate cancer, bicalutamide significantly improved objective PFS irrespective of the standard care received.

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Tolerability of nonsteroidal antiandrogens in the treatment of advanced prostate cancer.

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In this group, 74% of patients experienced a testosterone surge, vs 81% who took leuprolide without bicalutamide.

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Second, a project was begun to review the available quality-of-life measures and determine if reliable quality-of-life differences could be assessed for the alternative prostate cancer treatments.

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What tests can be done to be certain that the urologist did not leave prostate tissue behind during prostatectomy.

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