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Thus, in men treated with castration, symptoms appear to be more severe and less prone to resolution than they are in postmenopausal women.
The clinical relevance of this has been shown in a recent Medical Research Council study in the United Kingdom involving 938 patients with locally advanced or asymptomatic metastatic prostate cancer.
Treatment of C4-2 cells with the MAP kinase inhibitor, UO126 in steroid depleted conditions, substantially decreases AR stability and protein expression, suggesting that enhanced autocrine growth factor signaling contributes to the maintenance of AR expression and facilitates AR activity in the absence of androgens.
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The influence of prior novel androgen receptor targeted therapy on the efficacy of cabazitaxel in men with metastatic castration-resistant prostate cancer.
First, there are very few trials investigating a direct comparison of two different treatment modalities (e.
The frequency of adverse events was compared using the 2 test.
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The test measures the levels of this genetic fragment and another genetic marker (PCA3) in urine which are detectable at high levels in men who have prostate cancer.
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Tombal and Berges noted that 1 patient in their leuprolide gel study experienced a testosterone breakthrough.
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The operative group in the BRAVO study was drawn from a number of surgical practices that volunteered to participate in the study; no details are provided about how each center selected candidates for reduction mammaplasty, or how they chose patients who underwent mammaplasty for inclusion in the study.
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Before going further, the urologist asked Larry if he had any questions.
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Nervous system side effects including dizziness, paresthesia, and insomnia have been reported.
Source: Journal of the American Medical Association, July 27, 2005.
The attempts must be in clear, non-medical terms, so that the patient understands the issues.
The oxidizing agent to be used in Step C is preferably hydrogen peroxide from the aspect of environmental benignity.
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These axons come from the prostatic plexus, a collection of autonomic nerves and neurons that are trunks of the superior hypogastric plexus, a meshwork of nerves that lies anterior to the bifurcation of the aorta.
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However, another study found that low-dose bicalutamide administration resulted in testicular atrophy and reduced the count in the testes of male rats by almost 50%, though the rate of successful and pregnancy following was not assessed.
Stopping or slowing down the production of male hormones can slow down or stop the growth of prostate cancer cells, at least for a period of time that is not predictable at the present.
The historic investigations known as the Veterans Administration Cooperative Urological Research Group (VACURG) studies formed a basis for the treatment of prostate cancer with DES before the availability of LHRH analogues.
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The purpose of this visit is to discuss the role of radiation therapy in your treatment, to determine to be used, the treatment plan for your treatment, and to answer any questions you may have.
When Trial 24 data are combined with the data from the other two trials of the EPC programme, the overall EPC results demonstrate that, in patients with locally advanced prostate cancer, bicalutamide significantly improved objective PFS irrespective of the standard care received.
Most doctors prescribe an anti-androgen a little before LHRH agonist treatment begins and then continue it for another month afterwards.
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Tolerability of nonsteroidal antiandrogens in the treatment of advanced prostate cancer.
When a thin needle is used, the procedure is called a fine-needle aspiration biopsy.
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Er was onvoldoende bewijs van doeltreffendheid (bijvoorbeeld geen bewezen effect op de globale mortaliteit, en bij de patiënten met gelokaliseerde prostaatkanker mogelijk zelfs verhoogde mortaliteit).
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DHT (or R1881) fell within a reasonable range (12-57%) for all test systems (Table 2).
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In this group, 74% of patients experienced a testosterone surge, vs 81% who took leuprolide without bicalutamide.
There is a period of time where PSA will initially increase after radiation treatment.
It is also a non-steroidal anti-androgen so I'm hopeful that I'll get less side effects from it.
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Second, a project was begun to review the available quality-of-life measures and determine if reliable quality-of-life differences could be assessed for the alternative prostate cancer treatments.
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Structural modifications of bicalutamide led to the discovery of the first nonsteroidal androgens (the aryl propionamides) in 1998.
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Sexual activity may be a way of relaxing, working through difficult emotions, coping with difficult times, or boosting self-esteem.
What tests can be done to be certain that the urologist did not leave prostate tissue behind during prostatectomy.
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Based on crystal structures, compounds with ether linkage appear to adapt a more compact conformation than bicalutamide due to formation of an intramolecular H bond, allowing the B-ring to avoid steric conflict with the side chain of W741 in AR, and potentially explaining the agonist activity ().
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