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The combination of capecitabine and rIFN- is particularly attractive in view of the potential effects of rIFN- on dThdPase gene expression and the associated potentiation of capecitabine activity as a result of effects on fluoropyrimidine metabolism and interactions with tumor angiogenesis.
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Since histological appearance do not correlate well to biological behavior malignancy grading is not used with GIST, instead a risk evaluation according the following table is performed.
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Secondary endpoints included progression-free survival (time from first dose of chemotherapy until documentation of tumor progression, initiation of other cancer treatment, or death), overall survival (time from first dose of chemotherapy until death from any cause), and duration of response.
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Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study.
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